Effect of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammatio

Recent advances have shown how polyunsaturated fatty acids (PUFAs) regulate molecular signaling, especially in the context of inflammation. Nutritional intervention/ supplementation with PUFAs in experimental animal models have exhibited anti-inflammatory properties. In this study, chronic inflammation was assayed by cotton pellet-induced granuloma method to evaluate the anti-inflammatory and anti-granuloma effects of omega-3-polyunsaturated fatty acid using experimentally induced inflammatory models in rats. Obtained results indicate that omega-3 oil extract significantly (p<0.05) reduced the granuloma tissue formation (58.36 ± 3.52, 65.40 ± 1.30, 57.78 ± 3.89, 50.93 ± 0.60 and 42.17 ± 0.70 mg) representing 33.78, 25.79, 34.44, 42.21 and 52.15 % inhibition respectively for the proliferative phase when compared to the control. These results showed that omega-3 oil extract studied, possess both anti-inflammatory and anti-granuloma properties.